Vote for the next target!
Dear all, we have obtained results for different targets of SARS-CoV-2. The computations continue, and we want to ask your opinion on the next target. You can vote for one of them until February 5th, 2024.

  • SARS-CoV-2 main protease (3CLpro) further studies

    This is a crucial therapeutic target against SARS-CoV-2. 3CLpro (cysteine protease; EC in particular is crucial for the cleavage of coronavirus polyproteins to form mature non-structural proteins that are themselves essential for viral replication mechanisms. We still need much more research on this target towards new more potent inhibitors.

  • Ebolavirus glycoprotein (GP)

    Ebola virus is a dangerous pathogen to humans and this target could be a perfect study case for PPI-type drug design scenario. The EBOV glycoprotein (GP) is the only virally expressed protein on the virion surface and is critical for attachment to host cells and catalysis of membrane fusion.

  • Swine acute diarrhea syndrome coronavirus (SADS-CoV PLpro)

    This target would enable us to study the design on multiple related viral targets. Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus, is considered to be associated with swine acute diarrhea syndrome (SADS) which has caused significantly economic losses to the porcine industry. The pathogen indicates towards host-jump potential.

26 Jan 2024, 12:36:20 UTC · Discuss

Project server maintenance 17th January 2024
Dear participants, tomorrow, 2024.01.17 due to server maintenance, the project will stopped for several hours.

Thank you for attention and project participation!
16 Jan 2024, 12:54:07 UTC · Discuss

Project status: December 2023
Dear SiDock@home participants,

We've successfully achieved 21 milestones in our ongoing drug discovery initiative, and this strong, open, and community-supported drug discovery project is going on. Our research has been routine lately: virtual screening on the same library for a pleiade of corona-related targets. These efforts are however crucial to our research progression. Currently, we're in the process of drafting publications for two of our completed objectives (3CLpro and PLpro) and are setting the stage for upcoming drug targets (here we are also planning a pool where You the participants, will help us decide on the upcoming target work).
Last but not least, we thank everyone who has donated cryptocurrency or money. The donations sum up to 639 Euro and 12,140 Gridcoin now. We plan to use them for purchase of compounds and in-vitro screening. As always, we are grateful to all of you for your computational contributions and discussions!

We look forward to the future work on SiDock@home.

Merry Christmas to all and all the best to All!

With best wishes,
Natalia, Marko, Črtomir and hoarfrost

26 Dec 2023, 19:37:17 UTC · Discuss

Changes in task scheduling and monitoring mechanism
Dear participants, at the start of the current search, we set a deadline for "CmDock long tasks" to 14 days. But the average time required to process a task is 40 hours. Also, we see many of uncompleted tasks which prevent completion of the set to which they belong, "produced" by the computers that get tasks and do not get in touch again. Due to these reasons, we plan:
1. To perform a gradual reduction of the deadline;
2. To implement a simple mechanism which finds computers that are lost in computing space (those who did not send requests to the server in the last m days), and mark their tasks as lost. For example, m may be 10, 8, 6 or 5.

This should not interfere with computers actually participating in the calculations, but can greatly enhance the logistics of results.
6 Nov 2023, 10:05:37 UTC · Discuss

BOINC merchandise by the Science Commons Initiative
Dear participants,

There is a wonderful new beginning started by the Science Commons Initiative. They launched a web store selling BOINC-related merchandise. SiDock@home is already on board :)

We support this idea and hope it will help more people to know about BOINC and get interested in BOINC projects! It will also contribute to the development of BOINC as 50% of the profits will go to the BOINC Development Fund (100% in special cases). Another 50% of the profit will go to the project as a donation.

With best wishes,
team of SiDock@home
23 Feb 2023, 9:29:38 UTC · Discuss

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What is SiDock@home?

Sidock@home is an international volunteer computing project aimed at drug discovery. The first mission of the project is discovery of possible drugs against the SARS-CoV-2 virus. It started as an extension of the project  COVID.SI to engage the BOINC community into the drug discovery.

You can help with your computer. With the help of BOINC, you will download a subset of compounds on your computer, examine the compounds in the context of the studied target and send the results to a server where they are collected for later analysis.

For account creation please use a Crunch_4Science invitation code. It is not needed when registering by BOINC Manager.

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User of the Day

User profile Profile Tuna Ertemalp
Born in Germany (Öhringen), raised in Turkey (Istanbul), all grown up in USA (Seattle). Boğaziçi University, Istanbul, Turkey, 1983-1988: BS in...

Donations to SiDock@home

We are going to use donation money for biological evaluation of results.

This project is accepting donations in cryptocurrency:
  • Gridcoin wallet (GRC): SLymYcWWoJrC3vZ1fF4ZVebfbzfs9Kziy9
  • Bitcoin wallet (BTC): 3GaQD2EBsEAgvdPdpkMGJP3JT5zM3uKNn3
  • Ethereum wallet (ETH): 0xd726c8a048c0532e4793D88895d3cE1A637517c8
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