News

SiDock@home gets supported by the Charity Event 2022 (15 - 30 January)
Dear folks!

Charity Event team invites you to take part in the Charity Event 2022 addressing SiDock@home. You can read more about this event in thread on project forum and general forum of all Charity Events.

Thank you for attention to the project and participation!
6 Jan 2022, 17:00:32 UTC · Discuss


Merry Christmas!
Dear participants,

Merry Christmas and a happy New Year to all of you! We wish you lots of health, love and joy.

With Your help, we have done an enormous research work, and we are preparing to do even more and take this drug discovery project even further. We will be tackling future key problems in drug design and are working hard to overcome all obstacles of financing (with your help it is easier… thank You all!!!) and wet lab support!

Currently, we are finishing the 5th target and also returning to 3CLpro allosteric sites towards further in depth research.

All the best! From Natalia, Marko, Črtomir and hoarfrost
26 Dec 2021, 13:20:13 UTC · Discuss


A poll about distributed computing projects
Dear all,

there is a poll created by students who investigate volunteer computing. The questions aim to explore the motivation of participants. If you wish and have a minute, please express your opinion at https://forms.gle/tcLYdtoeVfMMREPE7. The results will be analyzed and presented to the public. Thank you!

With best wishes,
Team of SiDock@home
24 Nov 2021, 11:51:31 UTC · Discuss


Release CmDock v 0.1.4
Dear community. New release of CmDock was prepared. The v0.1.4 of CmDock incorporates fixed checkpointing and progress bar patch along with support for compressed input and output via cmzip. New CmDock release also includes an Updated SDF-Tools submodule that should help the userbase manipulate input/output files with support for large molecular libraries.

Along with the new release, BOINC client is up to date also. The team is working hard and we are committed to support CmDock in the future. Thank You!

Marko & Natalia
21 Nov 2021, 17:10:00 UTC · Discuss


Ninth and tenth targets
Dear participants,

We have a new target which resides at a novel allosteric site on SARS-CoV-2 main protease. The site was identified by MixMD method [1] with collaboration at College of Pharmacy, University of Michigan. Target preparation was helped by Jelena Tošović (Slovenia).

The two upcoming targets and results will complement the allosteric sites identified with X-ray screening by Sebastian Günther et al. [2]. The targets have good chances for wet-lab testing as soon as possible and further experimental support.

(We will again temporarily pause processing of Target 5)

With best wishes,
Team SiDock@home

[1] Phani Ghanakota and Heather A. Carlson. Moving Beyond Active-Site Detection: MixMD Applied to Allosteric Systems. The Journal of Physical Chemistry B 2016 120 (33), 8685-8695. DOI: 10.1021/acs.jpcb.6b03515
[2] Sebastian Günther et al. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science 2021 372 (6542), 642-646. DOI: 10.1126/science.abf7945
13 Nov 2021, 9:39:16 UTC · Discuss


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What is SiDock@home?

Sidock@home is an international volunteer computing project aimed at drug discovery. The first mission of the project is discovery of possible drugs against the SARS-CoV-2 virus. It started as an extension of the project  COVID.SI to engage the BOINC community into the drug discovery.

You can help with your computer. With the help of BOINC, you will download a subset of compounds on your computer, examine the compounds in the context of the studied target and send the results to a server where they are collected for later analysis.

For account creation please use a Crunch_4Science invitation code. It is not needed when registering by BOINC Manager.

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We are going to use donation money for biological evaluation of results.

This project is accepting donations in cryptocurrency:
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  • Bitcoin wallet (BTC): 3GaQD2EBsEAgvdPdpkMGJP3JT5zM3uKNn3
  • Ethereum wallet (ETH): 0xd726c8a048c0532e4793D88895d3cE1A637517c8
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